Fmoc-N-Me-Val-Val CAS 3119888-44-4 Dipeptide Derivative SPPS Intermediate

The product is mainly used in Fmoc-based solid-phase peptide synthesis (SPPS) for the efficient incorporation of an N-methylated hydrophobic dipeptide fragment into peptide sequences.

Compared with introducing amino acids step-by-step, the use of pre-assembled dipeptide building blocks can:

• Improve coupling efficiency
• Reduce racemization risk
• Simplify difficult peptide synthesis
• Increase overall peptide yield
• Minimize steric hindrance during elongation

This is particularly valuable for synthesizing:

• Long peptides
• Sterically hindered sequences
• Aggregation-prone peptides

The N-methyl amino acid structure is an important modification strategy in medicinal peptide chemistry.

Incorporation of the N-methylated Val-Val motif can:

• Enhance enzymatic stability
• Improve resistance to protease degradation
• Reduce intermolecular hydrogen bonding
• Modify peptide secondary structure
• Increase lipophilicity
• Improve membrane permeability
• Potentially enhance oral bioavailability

Therefore, this building block is frequently used in:

• Therapeutic peptide optimization
• Peptide lead modification
• Structure-activity relationship (SAR) studies

The compound is commonly applied in the synthesis of:

• Cyclic peptides
• Stapled peptides
• Lipopeptides
• Peptidomimetics
• Constrained peptide analogs

The hydrophobic Val-Val sequence combined with N-methylation helps:

• Stabilize bioactive conformations
• Improve receptor selectivity
• Reduce peptide flexibility
• Enhance pharmacokinetic properties

Such strategies are widely adopted in next-generation peptide therapeutics.

This intermediate is frequently utilized in:

• Peptide drug discovery programs
• GLP-1 analog development
• Oncology peptide research
• Antimicrobial peptide optimization
• CNS-targeting peptide studies

N-methylated peptide fragments are especially important in projects aiming to improve:

• Half-life
• Tissue penetration
• Oral delivery potential
• In vivo stability

The product is also used by:

• Peptide CROs
• CDMOs
• Pharmaceutical companies
• Academic peptide research laboratories

Typical applications include:

• Custom peptide synthesis
• GMP peptide manufacturing
• Advanced peptide intermediate production
• Process development and scale-up